Oral administration of gemcitabine in patients with refractory tumors: a clinical and pharmacologic study.

@article{Veltkamp2008OralAO,
  title={Oral administration of gemcitabine in patients with refractory tumors: a clinical and pharmacologic study.},
  author={Stephan A. Veltkamp and Robert S. Jansen and Sophie Callies and Dick Pluim and Carla M Visseren-Grul and Hilde Rosing and Susanne Kloeker-Rhoades and Valerie A M Andre and Jos H. Beijnen and Christopher A. Slapak and Jan H. M. Schellens},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2008},
  volume={14 11},
  pages={3477-86}
}
PURPOSE To determine the toxicity, tolerability, pharmacokinetics, pharmacodynamics, and preliminary antitumor activity of oral gemcitabine (2',2'-difluorodeoxycytidine; dFdC) in patients with cancer. EXPERIMENTAL DESIGN Patients with advanced or metastatic cancer refractory to standard therapy were eligible. Gemcitabine was administered p.o. starting at 1 mg once daily using dose escalation with three patients per dose level. Patients received one of two dosing schemes: (a) once daily dosing… CONTINUE READING
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