Oral administration of chitin down-regulates serum IgE levels and lung eosinophilia in the allergic mouse.

@article{Shibata2000OralAO,
  title={Oral administration of chitin down-regulates serum IgE levels and lung eosinophilia in the allergic mouse.},
  author={Yoshisada Shibata and Lorie A. Foster and John F. Bradfield and Quentin N. Myrvik},
  journal={Journal of immunology},
  year={2000},
  volume={164 3},
  pages={1314-21}
}
Previous studies showed that local macrophages phagocytose nonantigenic chitin particles (1-10 micrometer polymers of N-acetyl-d -glucosamine) through mannose receptors and produce IL-12, IL-18, and TNF-alpha. These cytokines lead to the production of IFN-gamma by NK cells. To determine whether chitin could down-regulate Th2 responses, chitin was given orally (8 mg/day for 3 days before and 13 days during ragweed allergen immunization) in BALB/c and C57BL/6 mice. These ragweed-immunized mice… CONTINUE READING