Oral administration of caffeic acid ameliorates the effect of cisplatin on brush border membrane enzymes and antioxidant system in rat intestine.

@article{Arivarasu2013OralAO,
  title={Oral administration of caffeic acid ameliorates the effect of cisplatin on brush border membrane enzymes and antioxidant system in rat intestine.},
  author={Natarajan A Arivarasu and Shubha Priyamvada and Riaz Mahmood},
  journal={Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie},
  year={2013},
  volume={65 1-2},
  pages={21-5}
}
Cisplatin (CP) is a widely used antineoplastic drug that exhibits gastrointestinal toxicity. We have previously shown that administration of a single dose of CP results in a decrease in the activities of several brush border membrane (BBM) enzymes, induces oxidative stress and alters the activities of several antioxidant enzymes in the small intestine of rats. In the present study we have investigated the effect of treatment with the dietary antioxidant caffeic acid (CA) on CP induced… CONTINUE READING

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