Oral administration of allergen extracts from Dermatophagoides farinae desensitizes specific allergen-induced inflammation and airway hyperresponsiveness in rats.

@article{Xie2008OralAO,
  title={Oral administration of allergen extracts from Dermatophagoides farinae desensitizes specific allergen-induced inflammation and airway hyperresponsiveness in rats.},
  author={Qiang-min Xie and Ximei Wu and Hui-min Wu and Yang-mei Deng and Shui-juan Zhang and Jian-ping Zhu and Xin-wei Dong},
  journal={International immunopharmacology},
  year={2008},
  volume={8 12},
  pages={1639-45}
}
Clinically sublingual immunotherapy (SLIT) by using allergen extracts effectively alleviates the symptoms of allergic rhinitis and asthma. Supposed that oral administration of high-dose of allergen extracts imitates SLIT and may prevent IgE-related responses in allergic diseases, we investigated the effects of oral administration of allergen extracts from Dermatophagoides farinae (Derf) on allergen-induced inflammation and airway hyperresponsiveness (AHR) in a model of asthmatic rat. After… CONTINUE READING