Oral administration of a small molecule targeted to block proNGF binding to p75 promotes myelin sparing and functional recovery after spinal cord injury.

@article{Tep2013OralAO,
  title={Oral administration of a small molecule targeted to block proNGF binding to p75 promotes myelin sparing and functional recovery after spinal cord injury.},
  author={Chhavy Tep and Tae Hee Lim and Pyung On Ko and Sami Getahun and Jae Cheon Ryu and Virginia M. Goettl and Stephen M Massa and Michele Basso and Frank M Longo and Sung Ok Yoon},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2013},
  volume={33 2},
  pages={397-410}
}
The lack of effective therapies for spinal cord injury points to the need for identifying novel targets for therapeutic intervention. Here we report that a small molecule, LM11A-31, developed to block proNGF-p75 interaction and p75-mediated cell death crosses the blood-brain barrier efficiently when delivered orally. Administered starting 4 h postinjury, LM11A-31 promotes functional recovery without causing any toxicity or increased pain in a mouse model of spinal contusion injury. In both… CONTINUE READING
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