Oral administration of a prodrug of the influenza virus neuraminidase inhibitor GS 4071 protects mice and ferrets against influenza infection.

@article{Mendel1998OralAO,
  title={Oral administration of a prodrug of the influenza virus neuraminidase inhibitor GS 4071 protects mice and ferrets against influenza infection.},
  author={Dirk B. Mendel and C. Y. D. Tai and Paul A. Escarpe and Weiguang Li and Robert W. Sidwell and John Henry Huffman and Clive Sweet and Kenneth J Jakeman and James Merson and Steve Lacy and Willard Lew and Mark Anthony Williams and Lijun Zhang and Ming Shuai Chen and Norbert Bischofberger and Choung Un Kim},
  journal={Antimicrobial agents and chemotherapy},
  year={1998},
  volume={42 3},
  pages={
          640-6
        }
}
We have recently described GS 4071, a carbocyclic transition-state analog inhibitor of the influenza virus neuraminidase, which has potent inhibitory activity comparable to that of 4-guanidino-Neu5Ac2en (GG167; zanamivir) when tested against influenza A virus replication and neuraminidase activity in vitro. We now report that GS 4071 is active against several strains of influenza A and B viruses in vitro and that oral GS 4104, an ethyl ester prodrug which is converted to GS 4071 in vivo, is… CONTINUE READING
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