Oral administration of Parabacteroides distasonis antigens attenuates experimental murine colitis through modulation of immunity and microbiota composition

@article{Kverka2011OralAO,
  title={Oral administration of Parabacteroides distasonis antigens attenuates experimental murine colitis through modulation of immunity and microbiota composition},
  author={Miloslav Kverka and Zuzana Jir{\'a}skov{\'a} Z{\'a}kostelsk{\'a} and Kl{\'a}ra Klime{\vs}ov{\'a} and Dan Sokol and Tomas Hudcovic and Tomas Hrncir and Pavel Rossmann and Jakub Mr{\'a}zek and Jan Kope{\vc}n{\'y} and Elena F. Verdu and Helena Tlaskalova-Hogenova},
  journal={Clinical \& Experimental Immunology},
  year={2011},
  volume={163}
}
Commensal bacteria have been shown to modulate the host mucosal immune system. Here, we report that oral treatment of BALB/c mice with components from the commensal, Parabacteroides distasonis, significantly reduces the severity of intestinal inflammation in murine models of acute and chronic colitis induced by dextran sulphate sodium (DSS). The membranous fraction of P. distasonis (mPd) prevented DSS‐induced increases in several proinflammatory cytokines, increased mPd‐specific serum… Expand
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