Oral administration of L-arginine potentiates allergen-induced airway inflammation and expression of interleukin-5 in mice.

Abstract

The role of nitric oxide in the airway hyperresponsiveness and inflammation of bronchial asthma has not yet been established. However, L-arginine, the substrate for nitric oxide synthases, reportedly alleviates airway hyperresponsiveness caused by parainfluenza virus and reduces granulocytic inflammation induced by ischemia-reperfusion. We investigated the… (More)

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@article{Takano1998OralAO, title={Oral administration of L-arginine potentiates allergen-induced airway inflammation and expression of interleukin-5 in mice.}, author={H. Takano and Hyun-Sul Lim and Yuko Miyabara and T. Ichinose and Takahisa Yoshikawa and Masaru Sagai}, journal={The Journal of pharmacology and experimental therapeutics}, year={1998}, volume={286 2}, pages={767-71} }