Oral acyclovir to suppress frequently recurrent herpes labialis. A double-blind, placebo-controlled trial.

@article{Rooney1993OralAT,
  title={Oral acyclovir to suppress frequently recurrent herpes labialis. A double-blind, placebo-controlled trial.},
  author={James F. Rooney and Stephen E. Straus and M M Mannix and Charles Wohlenberg and David W. Alling and Juan A Dumois and Abner Louis Notkins},
  journal={Annals of internal medicine},
  year={1993},
  volume={118 4},
  pages={268-72}
}
OBJECTIVE To determine whether oral acyclovir reduces the incidence of recurrent herpes labialis in otherwise healthy patients with proven frequently recurrent disease. DESIGN Randomized, double-blind, placebo-controlled, crossover trial. SETTING Outpatient facility of the Clinical Center, National Institutes of Health, Bethesda, Maryland. PATIENTS Fifty-six otherwise healthy adults who reported frequently recurrent herpes labialis (> or = 6 episodes/y) were enrolled into the study… CONTINUE READING