Oral activated charcoal and dapsone elimination.

  title={Oral activated charcoal and dapsone elimination.},
  author={Pertti J Neuvonen and Erkki Elonen and Mauri J. Mattila},
  journal={Clinical pharmacology and therapeutics},
  volume={27 6},
The effect of orally given activated charcoal on the elimination of therapeutic and toxic doses of dapsone was studied in 5 healthy subjects and in 2 intoxicated patients. In a randomized crossover study the subjects took a total dose of 500 mg dapsone over 4 days; 10 hr after the last 100-mg dose of dapsone 50 gm activated charcoal as a water suspension (or water) was taken, followed by 4 consecutive doses of 17 gm at 12-hr intervals. The half-life (t 1/2) of serum dapsone was 20.5 +/- 2.0 hr… CONTINUE READING

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