Oral acetylcysteine as an adjunct to saline hydration for the prevention of contrast-induced nephropathy following coronary angiography. A randomized controlled trial and review of the current literature.

@article{Goldenberg2004OralAA,
  title={Oral acetylcysteine as an adjunct to saline hydration for the prevention of contrast-induced nephropathy following coronary angiography. A randomized controlled trial and review of the current literature.},
  author={Ilan Goldenberg and Michael Shechter and Shlomi Matetzky and Michael Jonas and Miriam Adam and Hanna Pres and Dan Elian and Oren Agranat and Ehud E Schwammenthal and Victor Guetta},
  journal={European heart journal},
  year={2004},
  volume={25 3},
  pages={212-8}
}
AIMS To determine laboratory and clinical benefit of oral acetylcysteine, as an adjunct to saline hydration, in chronic renal insufficiency patients undergoing coronary angiography. METHODS AND RESULTS We prospectively studied 80 patients with chronic renal insufficiency (mean [+/-SD] serum creatinine concentration 2.0+/-0.39mg/dl), who underwent coronary angiography with or without intervention. Patients were randomly assigned to receive either acetylcysteine (600mg orally t.i.d.) or placebo… CONTINUE READING
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