Oral absorption profile of nitrendipine in healthy subjects: a kinetic and dynamic study.

@article{Soons1989OralAP,
  title={Oral absorption profile of nitrendipine in healthy subjects: a kinetic and dynamic study.},
  author={Petrus Soons and Albertus G de Boer and P van Brummelen and D. D. Breimer},
  journal={British journal of clinical pharmacology},
  year={1989},
  volume={27 2},
  pages={179-89}
}
1. In nine healthy male subjects the kinetics of nitrendipine were assessed after i.v. administration and its absorption profile was studied when given by a tablet formulation and by an osmotic pumping device (Osmet) with a zero-order in vitro release of 2.62 +/- 0.19 mg h-1 for 13 h. 2. Plasma concentrations of nitrendipine and its pyridine metabolite, heart rate and blood pressure were determined at regular intervals after drug administration. 3. After i.v. nitrendipine, the plasma… CONTINUE READING
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