Oral absorption of tacrolimus in children with intestinal failure due to short or absent small bowel.

@article{Novelli1999OralAO,
  title={Oral absorption of tacrolimus in children with intestinal failure due to short or absent small bowel.},
  author={Marco R. Novelli and Paolo Muiesan and Giorgina Mieli-Vergani and Anil Dhawan and Mohamed Rela and Nigel David Heaton},
  journal={Transplant international : official journal of the European Society for Organ Transplantation},
  year={1999},
  volume={12 6},
  pages={463-5}
}
We describe two children with intestinal failure due to short or absent small bowel who underwent isolated liver transplantation for liver disease related to parenteral nutrition. Both received reduced-size liver grafts whilst awaiting a suitable small bowel donor. Immunosuppressive therapy was based on oral tacrolimus and intravenous steroids. Therapeutic levels of tacrolimus were achieved at low dosage of 0.14-0.28 mg/kg per day. Median and mean blood tacrolimus levels were 9.9 and 13.7 ng/ml… CONTINUE READING

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