Oral absorption of ampicillin: role of paracellular route vs. PepT1 transporter.

@article{Lafforgue2008OralAO,
  title={Oral absorption of ampicillin: role of paracellular route vs. PepT1 transporter.},
  author={Guyl{\`e}ne Lafforgue and C{\'e}cile Arellano and Christelle Vachoux and John Woodley and Claude Philibert and V{\'e}ronique Dupouy and Alain Bousquet-M{\'e}lou and Peggy Gandia and Georges Houin},
  journal={Fundamental & clinical pharmacology},
  year={2008},
  volume={22 2},
  pages={189-201}
}
The beta-lactam antibiotic ampicillin has a relatively poor oral bioavailability in animals and man (30-40%), and its widespread agricultural use in livestock may be contributing to the emergence of antibiotic resistance in the environment. The aim of this study was to define the absorption mechanism by which ampicillin crosses the small intestinal epithelium. The improved rat everted gut sac system was used, with an emphasis on the role of the PepT1 transporter. The absorption kinetics… CONTINUE READING

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