Oral absorption and clearance of partially depolymerized fucosyl chondroitin sulfate from sea cucumber.

@article{Imanari1999OralAA,
  title={Oral absorption and clearance of partially depolymerized fucosyl chondroitin sulfate from sea cucumber.},
  author={Toshio Imanari and Yoshiaki Washio and Yi-Yong Huang and Hidenao Toyoda and Atsushi Suzuki and Toshihiko Toida},
  journal={Thrombosis research},
  year={1999},
  volume={93 3},
  pages={
          129-35
        }
}
Partially depolymerized holothurian glycosaminoglycan (DHG), a fucosyl chondroitin sulfate chains isolated from sea cucumber, was administered by the intravenous and oral routes to experimental animal. After intravenous injection, clearance of DHG, as measured by the postcolumn HPLC, displayed complex kinetics that were not dose dependent. DHG was excreted unchanged in the urine. No degradation products of DHG were detected by either gel filtration or anion exchange HPLC at any time in plasma… CONTINUE READING