Oral Zinc Therapy Normalizes Serum Uric Acid Level in Wilson's Disease Patients

@article{Umeki1986OralZT,
  title={Oral Zinc Therapy Normalizes Serum Uric Acid Level in Wilson's Disease Patients},
  author={Shigenobu Umeki and R Ohga and Yoshihiro Konishi and Takeshi Yasuda and K Morimoto and A. Terao},
  journal={THE AMERICAN JOURNAL OF THE MEDICAL SCIENCES},
  year={1986},
  volume={292},
  pages={289–292}
}
  • S. Umeki, R. Ohga, A. Terao
  • Published 1 November 1986
  • Medicine
  • THE AMERICAN JOURNAL OF THE MEDICAL SCIENCES
The authors investigated changes in the serum uric acid (s-UrA) level seen in a Wilson's disease patient who had to undergo oral zinc therapy because of the occurrence of D-penicillamine-induced acute sensitivity reactions, including neutrophilic agranulocytosis, thrombocytopenia, and skin eruptions. Although s-UrA levels were low before oral zinc therapy (mean ± SD, 1.60 ± 0.20), they increased (mean ± SD, 2.63 ± 0.32) to within normal range (2.8–8.0 mg/dl) after therapy. There were no… 
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Renal impairment in different phenotypes of Wilson disease
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Investigating the blood urea nitrogen, creatinine, and uric acid levels in different subtypes of Wilson's disease found that the levels of BUN and Cr in WD patients who had neurological manifestations were higher, and those patients presenting with a combined neurological and hepatic condition showed the lowest serum levels of UA.
Metabolomics profiles of patients with Wilson disease reveal a distinct metabolic signature
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Patients with Wilson disease are characterized by a distinct metabolomics profile providing new insights into WD pathogenesis and identifying new potential diagnostic biomarkers.
Association between low dietary zinc and hyperuricaemia in middle-aged and older males in China: a cross-sectional study
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The findings of this cross-sectional study indicated that dietary zinc intake was inversely associated with hyperuricaemia in middle-aged and older males, but not in females.
Association between Dietary Zinc Intake and Hyperuricemia among Adults in the United States
TLDR
It is indicated that dietary zinc intake is inversely associated with HU in US men and women, independent of some major confounding factors.
Associations of plasma multiple metals with risk of hyperuricemia: A cross-sectional study in a mid-aged and older population of China.
Neurobiology of zinc and zinc-containing neurons.
Effects of Feeding a Dry or Fermented Restaurant Food Residue Mixture on Performance and Blood Profiles of Rats
TLDR
Improvements showed that compared with feeding a dry food residue-containing diet, feeding aerobically or anaerobically fermented diets showed better animal performance as indicated by higher feed efficiency and rat growth rate.
For peer review only Association between Low Dietary Zinc and Hyperuricaemia in Middle-aged and Older Males

References

SHOWING 1-10 OF 25 REFERENCES
Renal Function in Wilson's Disease: Response to Penicillamine Therapy
TLDR
Most patients with Wilson's disease showed improvement in all parameters of renal function with penicillamine therapy, and three patients who initially had severe renal dysfunction did not improve clinically during penicillsamine therapy.
Oral zinc therapy for Wilson's disease.
TLDR
Oral zinc therapy, used according to the regimen, may now be considered in the treatment of patients with penicillamine intolerance, however, it is premature to convert patients to zinc therapy if they tolerate penicillsamine well.
Elastase 1 Levels during Oral Zinc Therapy
TLDR
Normal range of urine amylase (u-AMY) activity was below 1300 IU/I, and normal range of serum alkaline phosphatase (s-AIP) activities was below 280* I80IU/I.
Renal urate excretion in patients with Wilson's disease.
TLDR
It appears that proximal reabsorption of urate may not be impaired and there is a positive correlation between excessive urate excretion and that of serine, arginine, valine, and glutamine, as well as the quantity of various types of amino acids excreted.
D-penicillamine and neutrophilic agranulocytosis.
TLDR
A positive result from a direct Coombs' test in a rheumatoid patient receiving D-penicillamine indicates that some immunologic mechanism may be responsible for D- penicillamines—induced neutrophilic agranulocytosis.
A method for the rapid determination of alkaline phosphates with five cubic millimeters of serum.
NEUTROPHILIC AGRANULOCYTOSIS DURING ADMINISTRATION OF PENICILLAMINE.
TLDR
A cytotoxic effect and not an immunologic mechanism was responsible for the neutrophilic agranulocytosis in the patients described, and previous therapy with adrenal corticosteroids in both patients may have played a role in the development of the hematological [ill]oxicity.
Serum Glutamic Pyruvic Transaminase in Cardiac and Hepatic Disease.∗
  • F. Wróblewski, J. S. Ladue
  • Medicine, Biology
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1956
Summary The measurement of SGP-T alterations has been found to be a useful tool in the diagnosis and study of acute hepatic disease and appears to be more sensitive than SGO-T in depicting acute…
The renal lesion in Wilson's disease
Hepatic copper–and zinc-binding proteins in ruminants
TLDR
A study by gel-filtration techniques of the soluble copper- and zinc-binding proteins in livers from calves and sheep of widely differing Cu and Zn status found that Zn was usually absent from the low-molecular-weight fraction in Zn-deficient or high-Cu livers, with Cu also being absent in the former instance.
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