Oral Zinc Therapy Normalizes Serum Uric Acid Level in Wilson's Disease Patients

@article{Umeki1986OralZT,
  title={Oral Zinc Therapy Normalizes Serum Uric Acid Level in Wilson's Disease Patients},
  author={Shigenobu Umeki and R Ohga and Yoshihiro Konishi and Takeshi Yasuda and K Morimoto and A. Terao},
  journal={THE AMERICAN JOURNAL OF THE MEDICAL SCIENCES},
  year={1986},
  volume={292},
  pages={289–292}
}
  • S. Umeki, R. Ohga, A. Terao
  • Published 1 November 1986
  • Medicine
  • THE AMERICAN JOURNAL OF THE MEDICAL SCIENCES
The authors investigated changes in the serum uric acid (s-UrA) level seen in a Wilson's disease patient who had to undergo oral zinc therapy because of the occurrence of D-penicillamine-induced acute sensitivity reactions, including neutrophilic agranulocytosis, thrombocytopenia, and skin eruptions. Although s-UrA levels were low before oral zinc therapy (mean ± SD, 1.60 ± 0.20), they increased (mean ± SD, 2.63 ± 0.32) to within normal range (2.8–8.0 mg/dl) after therapy. There were no… 
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TLDR
Most patients with Wilson's disease showed improvement in all parameters of renal function with penicillamine therapy, and three patients who initially had severe renal dysfunction did not improve clinically during penicillsamine therapy.
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TLDR
Oral zinc therapy, used according to the regimen, may now be considered in the treatment of patients with penicillamine intolerance, however, it is premature to convert patients to zinc therapy if they tolerate penicillsamine well.
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TLDR
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TLDR
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TLDR
A cytotoxic effect and not an immunologic mechanism was responsible for the neutrophilic agranulocytosis in the patients described, and previous therapy with adrenal corticosteroids in both patients may have played a role in the development of the hematological [ill]oxicity.
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  • Medicine, Biology
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
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Summary The measurement of SGP-T alterations has been found to be a useful tool in the diagnosis and study of acute hepatic disease and appears to be more sensitive than SGO-T in depicting acute
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TLDR
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