Oral Vitamin K Lowers the International Normalized Ratio More Rapidly Than Subcutaneous Vitamin K in the Treatment of Warfarin-Associated Coagulopathy

@article{Crowther2002OralVK,
  title={Oral Vitamin K Lowers the International Normalized Ratio More Rapidly Than Subcutaneous Vitamin K in the Treatment of Warfarin-Associated Coagulopathy},
  author={Mark Andrew Crowther and James D Douketis and Terri Schnurr and Luigi Steidl and Valentina Mera and Carolina Ultori and Achille Venco and Walter Ageno},
  journal={Annals of Internal Medicine},
  year={2002},
  volume={137},
  pages={251-254}
}
Context Giving vitamin K when stopping warfarin increases the rate at which the international normalized ratio (INR) returns to normal. Although many clinicians give vitamin K subcutaneously, it appears that oral vitamin K reduces INR more rapidly. Contribution This randomized, controlled trial compared oral with subcutaneous vitamin K for patients receiving warfarin who had an INR of 4.5 to 10.0 but no bleeding. Oral administration normalized the INR faster than the subcutaneous route… 
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TLDR
The hypothesis that bleeding events would be reduced was based on the previously published, smaller studies of low-dose oral vitamin K administered to various patient groups, and it was found that a consistent and rapid decrease in the INR after low- dose vitamin K was administered.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
In patients receiving warfarin who have asymptomatic excessive prolongations in their INR results, 1 mg of oral vitamin K reliably reduces the INR to the therapeutic range within 24 h, suggesting this therapy is more convenient, less expensive, and might be safer than parenteral vitamin K.
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