Oral Vancomycin Followed by Fecal Transplantation Versus Tapering Oral Vancomycin Treatment for Recurrent Clostridium difficile Infection: An Open-Label, Randomized Controlled Trial.

@article{Hota2017OralVF,
  title={Oral Vancomycin Followed by Fecal Transplantation Versus Tapering Oral Vancomycin Treatment for Recurrent Clostridium difficile Infection: An Open-Label, Randomized Controlled Trial.},
  author={Susy S. Hota and V Sales and George Tomlinson and Mary Jane Salpeter and Allison Mcgeer and Bryan Coburn and David S. Guttman and Donald Edward Low and Susan M. Poutanen},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2017},
  volume={64 3},
  pages={265-271}
}
BACKGROUND Fecal transplantation (FT) is a promising treatment for recurrent Clostridium difficile infection (CDI), but its true effectiveness remains unknown. We compared 14 days of oral vancomycin followed by a single FT by enema with oral vancomycin taper (standard of care) in adult patients experiencing acute recurrence of CDI. METHODS In a phase 2/3, single-center, open-label trial, participants from Ontario, Canada, experiencing recurrence of CDI were randomly assigned in a 1:1 ratio to… CONTINUE READING

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