Oral Treatment Targeting the Unfolded Protein Response Prevents Neurodegeneration and Clinical Disease in Prion-Infected Mice

@article{Moreno2013OralTT,
  title={Oral Treatment Targeting the Unfolded Protein Response Prevents Neurodegeneration and Clinical Disease in Prion-Infected Mice},
  author={Julie A Moreno and Mark Halliday and Colin Molloy and Helois Radford and Nicholas C. Verity and Jeffrey M. Axten and Catharine A. Ortori and Anne E. Willis and Peter M. Fischer and David A. Barrett and Giovanna R. Mallucci},
  journal={Science Translational Medicine},
  year={2013},
  volume={5},
  pages={206ra138 - 206ra138}
}
Pharmacological inhibition of PERK, the key kinase of the unfolded protein response that mediates translational shutdown, restores protein synthesis in prion-infected mice, thus preventing neurodegeneration and clinical disease. Perking Up Prion Disease Therapy There are no effective treatments for neurodegenerative disorders such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and prion disease. These diseases share common features, including the accumulation of misfolded disease… Expand
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