• DOI:10.1126/scitranslmed.3006767
Corpus ID: 25570626

Oral Treatment Targeting the Unfolded Protein Response Prevents Neurodegeneration and Clinical Disease in Prion-Infected Mice

@article{Moreno2013OralTT,
  title={Oral Treatment Targeting the Unfolded Protein Response Prevents Neurodegeneration and Clinical Disease in Prion-Infected Mice},
  author={Julie A. Moreno and M. Halliday and Colin Molloy and H. Radford and N. Verity and J. Axten and C. A. Ortori and A. Willis and P. Fischer and D. Barrett and G. Mallucci},
  journal={Science Translational Medicine},
  year={2013},
  volume={5},
  pages={206ra138 - 206ra138}
}

Julie A. Moreno, M. Halliday, +8 authors G. Mallucci

Published 2013

Biology, Medicine

Science Translational Medicine

Pharmacological inhibition of PERK, the key kinase of the unfolded protein response that mediates translational shutdown, restores protein synthesis in prion-infected mice, thus preventing neurodegeneration and clinical disease. Perking Up Prion Disease Therapy There are no effective treatments for neurodegenerative disorders such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and prion disease. These diseases share common features, including the accumulation of misfolded disease… CONTINUE READING

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