Oral Treatment Targeting the Unfolded Protein Response Prevents Neurodegeneration and Clinical Disease in Prion-Infected Mice

@article{Moreno2013OralTT,
  title={Oral Treatment Targeting the Unfolded Protein Response Prevents Neurodegeneration and Clinical Disease in Prion-Infected Mice},
  author={Julie A. Moreno and M. Halliday and Colin Molloy and H. Radford and N. Verity and J. Axten and C. A. Ortori and A. Willis and P. Fischer and D. Barrett and G. Mallucci},
  journal={Science Translational Medicine},
  year={2013},
  volume={5},
  pages={206ra138 - 206ra138}
}
  • Julie A. Moreno, M. Halliday, +8 authors G. Mallucci
  • Published 2013
  • Biology, Medicine
  • Science Translational Medicine
  • Pharmacological inhibition of PERK, the key kinase of the unfolded protein response that mediates translational shutdown, restores protein synthesis in prion-infected mice, thus preventing neurodegeneration and clinical disease. Perking Up Prion Disease Therapy There are no effective treatments for neurodegenerative disorders such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and prion disease. These diseases share common features, including the accumulation of misfolded disease… CONTINUE READING
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