Oral S-adenosylmethionine in depression: a randomized, double-blind, placebo-controlled trial.

@article{Kagan1990OralSI,
  title={Oral S-adenosylmethionine in depression: a randomized, double-blind, placebo-controlled trial.},
  author={Bruce L. Kagan and David L. Sultzer and Nicholas Z. Rosenlicht and Robert H. Gerner},
  journal={The American journal of psychiatry},
  year={1990},
  volume={147 5},
  pages={591-5}
}
Methylation has been implicated in the etiology of psychiatric illness. Parenteral S-adenosylmethionine, a methyl group donor, has been shown to be an effective antidepressant. The authors studied the antidepressant effect of oral S-adenosylmethionine in a randomized, double-blind, placebo-controlled trial for 15 inpatients with major depression. The results suggest that oral S-adenosylmethionine is a safe, effective antidepressant with few side effects and a rapid onset of action. S… CONTINUE READING

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