Oral N-acetylcysteine reduces bleomycin-induced lung damage and mucin Muc5ac expression in rats.

  title={Oral N-acetylcysteine reduces bleomycin-induced lung damage and mucin Muc5ac expression in rats.},
  author={Manuel Mata and Almodovar Ruiz and Miguel Jover Cerd{\'a} and Maleles Martinez-Losa and Julio Cortijo and Francesco Antonio Santangelo and Anna Serrano-Mollar and Antonio Llombart-Bosch and Esteban Jes{\'u}s Morcillo},
  journal={The European respiratory journal},
  volume={22 6},
Oxidative stress is involved in the pathogenesis of pulmonary fibrosis, therefore antioxidants may be of therapeutic value. Clinical work indicates that N-acetylcysteine (NAC) may be beneficial in this disease. The activity of this antioxidant was examined on bleomycin-induced lung damage, mucus secretory cells hyperplasia and mucin Muc5ac gene expression in rats. NAC (3 mmol x kg(-1) x day(-1)) or saline was given orally to Sprague-Dawley rats for 1 week prior to a single intratracheal… CONTINUE READING
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