Oral N-acetylcysteine attenuates pulmonary emphysema and alveolar septal cell apoptosis in smoking-induced COPD in rats.

@article{Cai2009OralNA,
  title={Oral N-acetylcysteine attenuates pulmonary emphysema and alveolar septal cell apoptosis in smoking-induced COPD in rats.},
  author={Shan Rong Cai and Ping Chen and Cheng Zhang and Jian-bo Chen and Jie Wu},
  journal={Respirology},
  year={2009},
  volume={14 3},
  pages={354-9}
}
BACKGROUND AND OBJECTIVE The role of apoptosis in lung destruction in emphysema/COPD is increasingly being recognized. The relationship between anti-oxidants and alveolar septal cell apoptosis in COPD lungs remains to be elucidated. The aim of this study was to investigate the effects of the anti-oxidant, N-acetylcysteine (NAC), on the development of emphysema and alveolar septal cell apoptosis in smoking-induced COPD in rats. METHODS Sprague-Dawley rats (n = 48) were randomly assigned to… CONTINUE READING
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