Oral Lichen Planus in IBD Patients: A Paradoxical Adverse Effect of Anti-TNF-α Therapy

Abstract

The efficacy of tumor necrosis factor alpha (TNF-α) inhibitors in the treatment of Inflammatory Bowel Disease (IBD) is well established. Many cutaneous and mucosal lesions have been described under anti-TNF-α therapy, some of them being considered as paradoxical. In this series we aimed to review the cases of oral lichen planus (OLP) in IBD patients under treatment with anti-TNF-α agents. Histologic findings from oral lesions of IBD patients treated with anti-TNF were revised. Three female patients with IBD developed oral lichen planus (OLP) after starting anti-TNF-α therapy. Other etiologies were excluded. In light of the increasing use of TNF-α inhibitors the occurrence of OLP is a potentially emerging side effect, thus we recommend a careful monitoring for oral manifestations in IBD patients treated with anti-TNF-α agents.

DOI: 10.1007/s10620-015-3680-2

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Cite this paper

@article{Andrade2015OralLP, title={Oral Lichen Planus in IBD Patients: A Paradoxical Adverse Effect of Anti-TNF-α Therapy}, author={Patricia Andrade and Susana Isabel Lopes and Andreia Albuquerque and Filipa Os{\'o}rio and J. L. Prada Pardal and Guilherme Macedo}, journal={Digestive Diseases and Sciences}, year={2015}, volume={60}, pages={2746-2749} }