Oral Leucine Supplementation Is Sensed by the Brain but neither Reduces Food Intake nor Induces an Anorectic Pattern of Gene Expression in the Hypothalamus

@inproceedings{Zampieri2013OralLS,
  title={Oral Leucine Supplementation Is Sensed by the Brain but neither Reduces Food Intake nor Induces an Anorectic Pattern of Gene Expression in the Hypothalamus},
  author={Thais Tessari Zampieri and Jo{\~a}o A. B. Pedroso and Isadora C Furigo and J{\'u}lio Tirapegui and Jos{\'e} Luiz Donato},
  booktitle={PloS one},
  year={2013}
}
Leucine activates the intracellular mammalian target of the rapamycin (mTOR) pathway, and hypothalamic mTOR signaling regulates food intake. Although central infusion of leucine reduces food intake, it is still uncertain whether oral leucine supplementation is able to affect the hypothalamic circuits that control energy balance. We observed increased phosphorylation of p70s6k in the mouse hypothalamus after an acute oral gavage of leucine. We then assessed whether acute oral gavage of leucine… CONTINUE READING