Oral L-citrulline administration improves memory deficits following transient brain ischemia through cerebrovascular protection.

@article{Yabuki2013OralLA,
  title={Oral L-citrulline administration improves memory deficits following transient brain ischemia through cerebrovascular protection.},
  author={Yasushi Yabuki and Norifumi Shioda and Yui Yamamoto and Miyuki Shigano and Kota Kumagai and Masahiko Morita and Kohji Fukunaga},
  journal={Brain research},
  year={2013},
  volume={1520},
  pages={157-67}
}
L-citrulline (L-Cit) is known to increase nitric oxide (NO) production via the increase of L-arginine (L-Arg) concentration in the blood and improve endothelial dysfunction in cardiovascular diseases. However, little is known about the effects of L-Cit on cerebrovascular dysfunction. Here we showed that oral L-Cit administration prevents cerebrovascular injury following cerebral ischemia using a 20-min bilateral common carotid artery occlusion (BCCAO) mouse model. After BCCAO ischemia, mice… CONTINUE READING