Oral L-arginine improves endothelial function in healthy individuals older than 70 years

@article{BodeBger2003OralLI,
  title={Oral L-arginine improves endothelial function in healthy individuals older than 70 years},
  author={S. Bode-B{\"o}ger and Jochen Muke and A. Surdacki and G. Brabant and R. B{\"o}ger and J. Fr{\"o}lich},
  journal={Vascular Medicine},
  year={2003},
  volume={8},
  pages={77 - 81}
}
Ageing is associated with progressive endothelial dysfunction in normal humans. Flow-mediated dilation (FMD) of the brachial artery is impaired in elderly individuals with cardiovascular disease and vascular nitric oxide (NO) bioavailability is reduced. We investigated whether oral L-arginine, the substrate for NO synthesis, can improve impaired FMD in healthy very old people. In a prospective, double-blind, randomized crossover trial, 12 healthy old subjects (age 73.8 6 2.7 years) took L… Expand
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