Oral L-arginine can reverse digital necrosis in Raynaud's phenomenon

  title={Oral L-arginine can reverse digital necrosis in Raynaud's phenomenon},
  author={Christopher M. Rembold and C. R. Ayers},
  journal={Molecular and Cellular Biochemistry},
Raynaud's phenomenon is characterized by transient reduction in blood supply through the small arteries in the hands and feet. Severe Raynaud's phenomenon can cause digital necrosis. It has been hypothesized that nitric oxide may have a role in Raynaud's phenomenon. We report two cases in which oral L-arginine reversed digital necrosis in Raynaud's phenomenon and two additional cases in which the symptoms of severe Raynaud's phenomenon were improved with oral L-arginine. These reports suggest… 

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While there is no established dosing regimen, studies of oral l_arginine in secondary RP suggest that divided dosing may begin at 1_2 g/day and may be titrated up to 10 g/ day.

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