Oral L‐glutamine increases GABA levels in striatal tissue and extracellular fluid

  title={Oral L‐glutamine increases GABA levels in striatal tissue and extracellular fluid},
  author={Lei Wang and Timothy J. Maher and Richard J. Wurtman},
  journal={The FASEB Journal},
  pages={1227 - 1232}
We explored the possibility that circulating glutamine affects γ‐aminobutyric acid (GABA) levels in rat striatal tissue and GABA concentrations in striatal extracellular fluid (ECF). Striatal microdialy‐sates, each collected over a 20 min interval, were obtained after no treatment, oral L‐glutamine (0.5 g/kg), or glutamine followed by NMDA (administered via the microdialysis probe). GABA concentrations were measured by HPLC using a stable OPA/sulfite precolumn derivatization and an… 

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