Oral Ketamine for the Treatment of Type I Complex Regional Pain Syndrome

@article{VillanuevaPerez2007OralKF,
  title={Oral Ketamine for the Treatment of Type I Complex Regional Pain Syndrome},
  author={Vicente L. Villanueva-Perez and Germ{\'a}n Cerd{\'a}-Olmedo and Juan Marcos Asensio Samper and Ana M{\'i}nguez and Vicente Monsalve and Maria Jose Bayona and Jose de Andr{\'e}s},
  journal={Pain Practice},
  year={2007},
  volume={7}
}
Abstract:  Ketamine has been shown to be effective in the treatment of neuropathic pain. We present a case of severe complex regional pain syndrome type 1 that was treated with oral ketamine. The response and tolerability of this preparation suggest that further study is warranted. 
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Based on the authors' experience with oral ketamine, this drug should be administered after an intravenous trial to monitor response and side effects in patients with an adequate functional status, however, patients in the palliative care and hospice setting, especially the one at the end of their lives, may also benefit from oral ketamines even if an intravenOUS trial is not feasible.
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TLDR
There is currently only weak evidence supporting the efficacy of ketamine for CRPS, yet there is clearly a rationale for definitive study.
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Oral ketamine, given for longer time periods in the described doses, appears to be well tolerated, but the short- and longer-term depression outcomes as well as side-effects need to be studied with rigorous randomised controlled trials.
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Improving the Diagnosis and Treatment of CRPS: Insights from a Clinical Immunologist’s Personal Experience with an Underrecognized Neuroinflammatory Disorder
  • K. Binkley
  • Medicine
    Journal of Neuroimmune Pharmacology
  • 2012
TLDR
Some of the specific barriers to diagnosis and treatment are reviewed, with suggestions as to how they might be eliminated, leading to better care for all patients with CRPS.
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References

SHOWING 1-10 OF 31 REFERENCES
Oral ketamine: a promising treatment for restless legs syndrome.
TLDR
Oral Ketamine, an NMDA receptor antagonist, can be used to treat restless legs syndrome and a mechanism for the efficacy of this treatment is discussed.
Analgesic effect of oral ketamine in chronic neuropathic pain of spinal origin: a case report.
Treatment of central post-stroke pain with oral ketamine
Oral ketamine therapy in the treatment of postamputation stump pain
Background: Hyperacti vity of N‐methy l‐D‐aspartate (NMD A) receptors may be one of the factors in the maintenance of post‐amputation stump pain.
Four years' treatment with ketamine and a trial of dextromethorphan in a patient with severe post‐herpetic neuralgia
TLDR
Ketamine, a non‐competitive NMDA receptor antagonist, has in several case reports given pain relief but efficacy in dosages tolerated in long‐term ketamine treatment is unknown.
Analgesic Effects of Ketamine Ointment in Patients With Complex Regional Pain Syndrome Type 1
TLDR
Topical application of KET appears to be beneficial for the patients with acute early dystrophic stage of CRPS I because of either its local anesthetic effect or NMDA receptor antagonist action.
Subanesthetic ketamine infusion therapy: a retrospective analysis of a novel therapeutic approach to complex regional pain syndrome.
TLDR
This retrospective review suggests that limited subanesthetic inpatient infusions of ketamine may offer a promising therapeutic option in the treatment of appropriately selected patients with intractable CRPS.
Ketamine patient-controlled analgesia for dysesthetic central pain
TLDR
Ketamine PCA may be a viable treatment option in patients suffering from intractable central pain, and the rationale for this treatment, along with dosing guidelines and possible drawbacks, is discussed.
Low dose ketamine as an analgesic adjuvant in difficult pain syndromes: a strategy for conversion from parenteral to oral ketamine.
Safety of mixture of morphine with ketamine for postoperative patient‐controlled analgesia: an audit with 1026 patients
TLDR
Adding ketamine to morphine for patient‐controlled analgesia (PCA) may be useful, but data on this drug combination have been collected on small sample sizes, so a prospective study on a large patient population is needed to evaluate the safety.
...
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