Oral Ixazomib, Lenalidomide, and Dexamethasone for Multiple Myeloma.

  title={Oral Ixazomib, Lenalidomide, and Dexamethasone for Multiple Myeloma.},
  author={Philippe Moreau and Tamas Masszi and Norbert Grząśko and Nizar Jacques Bahlis and Markus Hansson and Luděk Pour and Irwindeep Sandhu and P. S. Ganly and Bartrum W Baker and Sharon R. Jackson and A M Stoppa and David R Simpson and Peter Gimsing and Antonio Palumbo and Laurent Garderet and Michele Cavo and S K Praveen Kumar and Cyrille Touzeau and Francis K Buadi and Jacob P Laubach and Deborah T Berg and Jianchang Lin and Alessandra di Bacco and A M Hui and Helgi J K van de Velde and Paul G Richardson},
  journal={The New England journal of medicine},
  volume={374 17},
BACKGROUND Ixazomib is an oral proteasome inhibitor that is currently being studied for the treatment of multiple myeloma. METHODS In this double-blind, placebo-controlled, phase 3 trial, we randomly assigned 722 patients who had relapsed, refractory, or relapsed and refractory multiple myeloma to receive ixazomib plus lenalidomide-dexamethasone (ixazomib group) or placebo plus lenalidomide-dexamethasone (placebo group). The primary end point was progression-free survival. RESULTS… CONTINUE READING
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