Oral Human Papillomavirus in Healthy Individuals: A Systematic Review of the Literature

  title={Oral Human Papillomavirus in Healthy Individuals: A Systematic Review of the Literature},
  author={Aim{\'e}e R. Kreimer and Rohini K. Bhatia and Andrea L. Messeguer and Paula González and Rolando Herrero and Anna R. Giuliano},
  journal={Sexually Transmitted Diseases},
Background: Human papillomavirus type 16 (HPV16) is a common infection in the anogenital tract. HPV16 DNA detected in oral specimens has recently been identified as a risk factor for some oropharyngeal cancers. The reported prevalence of oral HPV infection from individual studies is highly variable. Methods: We systematically reviewed and abstracted data from published studies (n = 18) that detected oral HPV DNA in 4581 cancer-free subjects to determine the pooled prevalence (and 95% confidence… 

The Epidemiology of Oral HPV Infection among a Multinational Sample of Healthy Men

Oral HPV16 infection was rare in healthy men, especially at younger ages, and was positively associated with current tobacco use, and it remains unclear whether this reflects reduced exposure or if the oral region is more resistant to HPV infection compared with anogenital sites.

Risk Factors for Oral Human Papillomavirus Infection in Healthy Individuals: A Systematic Review and Meta-Analysis

The findings suggest that sexual behavior and smoking are importantly related to oral HPV infection in healthy individuals.

Oral Human Papillomavirus Infection and Its Risk Factors among 5,410 Healthy Adults in China, 2009–2011

Oral HPV infection, particularly with α mucosal types, is rare among healthy adults in China, and a younger age and a history of oral disease imply higher risk of α mucosa HPV infection.

National prevalence of oral HPV infection and related risk factors in the U.S. adult population.

The results provide population data that help evaluate the likely public health benefits of prophylactic vaccination against oral HPV acquisition and report the first nationally representative estimates of oral HPV prevalence in the United States adult population.

The Prevalence and Incidence of Oral Human Papillomavirus Infection Among Young Men and Women, Aged 18–30 Years

Evidence is provided that oral sexual contact in the form of both oral-oral and oral-genital contact could play a role in the transmission of oral HPV.

Oral Human Papillomavirus (HPV) Infection among Unvaccinated High-Risk Young Adults

Performing oral sex on a woman may confer higher risk of oral HPV acquisition than performing oralsex on a man, and male gender, number of recent oral sex partners and having ever performed oral sex with a woman were associated with increased oral HPV prevalence.

Prevalence of and Risk Factors for Oral Human Papillomavirus Infection With Multiple Genotypes in the United States

Men, smokers, and those who had new sexual partners were at a significantly higher risk of multitype oral HPV infection over single-type HPV infection.

Prevalence of Human Papillomavirus (HPV) in the Oral Cavity of a Healthy Population in South-Eastern Poland

The presence of HPV was statistically more frequent in the population living in urban rather than in rural areas in all studied age groups and a positive relationship was demonstrated between age and the amount of positive oral HPV.

Prevalence of human papillomaviruses in the mouths of New Zealand women.

The prevalence of HPV in the oral cavity of New Zealand woman was comparable to results of other studies, but showed an unusual distribution of HPV types, suggesting further work into clinical significance of oral HPV 13 infection is warranted.



Human Papillomavirus Types in Head and Neck Squamous Cell Carcinomas Worldwide: A Systematic Review

Tumor site–specific HPV prevalence was higher among studies from North America compared with Europe and Asia, and the high HPV16 prevalence and the lack of HPV18 in oropharyngeal compared with other HNSCCs may point to specific virus-tissue interactions.

The prevalence of human papillomavirus in the oropharynx in healthy individuals in a Brazilian population

This study shows the prevalence of HR HPV in the oropharynx of normal individuals, and if HPV infection in a healthy it is not known individual predisposes to HPV‐associated disease such as opharyngeal cancer.

Oral human papillomavirus infection in adults is associated with sexual behavior and HIV serostatus.

HPV type 16, which is present in most HPV-associated tonsillar cancers, was the most prevalent high-risk oral HPV infection.

Natural history of oral papillomavirus infections in spouses: a prospective Finnish HPV Family Study.

Epidemiologic classification of human papillomavirus types associated with cervical cancer.

In addition to HPV types 16 and 18, types 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68, 73, and 82Should be considered carcinogenic, or high-risk, types, and types 26, 53, and 66 should be considered probably carcinogenic.

Prevalence of Human Papillomavirus in the Oral Cavity/Oropharynx in a Large Population of Children and Adolescents

The age-specific prevalence rates of HPV in this large cross section of children and adolescents demonstrate that HPV infection is acquired gradually in childhood, and support a target age for HPV vaccination before puberty to prevent serious HPV-related genital and oral diseases.

Persistent human papillomavirus infection and cervical neoplasia: a systematic review and meta-analysis.

HPV persistence was consistently and strongly associated with high-grade cervical intraepithelial neoplasia and CIN2-3/HSIL+, despite wide variation in definitions and study methods.

Low prevalence of HPV infection and its natural history in normal oral mucosa among volunteers on Miyako Island, Japan.

  • K. KuroseM. Terai M. Takagi
  • Medicine, Biology
    Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
  • 2004

Relationship between Prevalent Oral and Cervical Human Papillomavirus Infections in Human Immunodeficiency Virus-Positive and -Negative Women

The oral and cervical reservoirs for HPV infection are likely not entirely independent of one another, according to the prevalences and type distributions compared with a cross-sectional study within the Women's Interagency HIV Study cohort.