Oral Human Papillomavirus in Healthy Individuals: A Systematic Review of the Literature

@article{Kreimer2010OralHP,
  title={Oral Human Papillomavirus in Healthy Individuals: A Systematic Review of the Literature},
  author={Aim{\'e}e R. Kreimer and Rohini K. Bhatia and Andrea L. Messeguer and Paula González and Rolando Herrero and Anna R. Giuliano},
  journal={Sexually Transmitted Diseases},
  year={2010},
  volume={37},
  pages={386-391}
}
Background: Human papillomavirus type 16 (HPV16) is a common infection in the anogenital tract. HPV16 DNA detected in oral specimens has recently been identified as a risk factor for some oropharyngeal cancers. The reported prevalence of oral HPV infection from individual studies is highly variable. Methods: We systematically reviewed and abstracted data from published studies (n = 18) that detected oral HPV DNA in 4581 cancer-free subjects to determine the pooled prevalence (and 95% confidence… 

The Epidemiology of Oral HPV Infection among a Multinational Sample of Healthy Men

Oral HPV16 infection was rare in healthy men, especially at younger ages, and was positively associated with current tobacco use, and it remains unclear whether this reflects reduced exposure or if the oral region is more resistant to HPV infection compared with anogenital sites.

Risk Factors for Oral Human Papillomavirus Infection in Healthy Individuals: A Systematic Review and Meta-Analysis

The findings suggest that sexual behavior and smoking are importantly related to oral HPV infection in healthy individuals.

Oral Human Papillomavirus Infection and Its Risk Factors among 5,410 Healthy Adults in China, 2009–2011

Oral HPV infection, particularly with α mucosal types, is rare among healthy adults in China, and a younger age and a history of oral disease imply higher risk of α mucosa HPV infection.

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The results provide population data that help evaluate the likely public health benefits of prophylactic vaccination against oral HPV acquisition and report the first nationally representative estimates of oral HPV prevalence in the United States adult population.

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Evidence is provided that oral sexual contact in the form of both oral-oral and oral-genital contact could play a role in the transmission of oral HPV.

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Performing oral sex on a woman may confer higher risk of oral HPV acquisition than performing oralsex on a man, and male gender, number of recent oral sex partners and having ever performed oral sex with a woman were associated with increased oral HPV prevalence.

Prevalence of and Risk Factors for Oral Human Papillomavirus Infection With Multiple Genotypes in the United States

Men, smokers, and those who had new sexual partners were at a significantly higher risk of multitype oral HPV infection over single-type HPV infection.

Prevalence of Human Papillomavirus (HPV) in the Oral Cavity of a Healthy Population in South-Eastern Poland

The presence of HPV was statistically more frequent in the population living in urban rather than in rural areas in all studied age groups and a positive relationship was demonstrated between age and the amount of positive oral HPV.

Prevalence of human papillomaviruses in the mouths of New Zealand women.

The prevalence of HPV in the oral cavity of New Zealand woman was comparable to results of other studies, but showed an unusual distribution of HPV types, suggesting further work into clinical significance of oral HPV 13 infection is warranted.
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