• DOI:10.1161/CIRCULATIONAHA.105.538520
Corpus ID: 24392101

Oral Human Brain Natriuretic Peptide Activates Cyclic Guanosine 3,5-Monophosphate and Decreases Mean Arterial Pressure

@article{Cataliotti2005OralHB,
  title={Oral Human Brain Natriuretic Peptide Activates Cyclic Guanosine 3,5-Monophosphate and Decreases Mean Arterial Pressure},
  author={A. Cataliotti and J. Schirger and F. L. Martin and H. Chen and P. McKie and G. Boerrigter and Lisa C. Costello-Boerrigter and G. Harty and D. Heublein and S. Sandberg and Kenneth D. James and M. Miller and N. B. Malkar and K. Polowy and J. Burnett},
  journal={Circulation},
  year={2005},
  volume={112},
  pages={836-840}
}

A. Cataliotti, J. Schirger, +12 authors J. Burnett

Published 2005

Medicine

Circulation

Background—The objective of this study was to address the feasibility and the biological activity of orally administered human brain natriuretic peptide (hBNP). Proprietary technology has been developed in which short, amphiphilic oligomers are covalently attached to peptides. The conjugated peptides are intended to have an improved pharmacokinetic profile and to enable oral administration. We hypothesized that novel oral conjugated hBNP (CONJ-hBNP) increases plasma hBNP, activates cGMP, and… CONTINUE READING

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