Oral Gene Delivery: An Innovative Approach for Colorectal Center Therapy

@article{Patel2020OralGD,
  title={Oral Gene Delivery: An Innovative Approach for Colorectal Center Therapy},
  author={Meghna Patel and Kinjal D. Patel and Devanshi Patel},
  journal={Journal of Drug Delivery and Therapeutics},
  year={2020},
  volume={10},
  pages={186-188}
}
Colorectal cancer is the third most commonly diagnosed cancer in the world characterized by neoplasia in the colon, rectum, or vermiform appendix. Current treatment approaches include chemotherapy, radiotherapy and surgery however non-specific bio-distribution of anti-cancer drug, lack of effective and safe drug delivery career, drug resistance and relapse are major limiting factors of current therapy. Gene therapy is a technique for correcting defective genes responsible for disease… 
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References

SHOWING 1-10 OF 44 REFERENCES
Macromolecular Drug Carriers for Targeted Glioblastoma Therapy: Preclinical Studies, Challenges, and Future Perspectives
TLDR
Current preclinical studies and future perspectives of targeted drug delivery to glioblastoma by macromolecular carrier systems, including polymeric micelles, nanoparticles, and biopolymers are explored.
Localized paclitaxel delivery.
Role of antibodies in diagnosis and treatment of ovarian cancer: Basic approach and clinical status.
  • P. Bhatt, I. Vhora, R. Mashru
  • Biology
    Journal of controlled release : official journal of the Controlled Release Society
  • 2016
Current Trends in Cancer Nanotheranostics: Metallic, Polymeric, and Lipid-Based Systems
TLDR
This review presents an updated description of nanotheranostic formulations under development for skin cancer, head and neck, thyroid, breast, gynecologic, prostate, and colon cancers, brain-related cancer, and hepatocellular carcinoma, highlighting the clinical advantages and drawbacks of metallic, polymeric, and lipid-based nanosystems.
Exploring targeted pulmonary delivery for treatment of lung cancer
TLDR
The research performed over the last and current decades on the delivery of various oncolytics for pulmonary delivery for the treatment of lung cancer and inhaled drug delivery devices in cancer therapy are reviewed.
Surface Modification of Nanoparticles for Targeted Drug Delivery
TLDR
Nanoparticles have been greatly advantageous in breaking through barrier of successful HIV therapy and to treat this retroviral disease, the use of solid lipid nanoparticles is made due to it being able to improve the long-term stability of colloidal nanoparticles.
Hereditary colorectal cancer syndromes
TLDR
The genetics, clinical manifestations and clinical management of each of these syndromes including Hereditary Nonpolyposis Colorectal Cancer (HNPCC), Family Polyposis (FAP) and the hamartomatous polyposis syndrome are summarized.
Genetics, inheritance and strategies for prevention in populations at high risk of colorectal cancer (CRC).
  • J. Burn, J. Mathers, D. Bishop
  • Medicine
    Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer
  • 2013
TLDR
There was no evidence that either agent influenced development of colonic neoplasia and the planned subgroup analyses of patients who elected to continue on study for more than one year found a significant reduction in the size of the largest polyp in the aspirin versus non-aspirin group.
Molecular genetics of colorectal cancer.
  • E. Fearon
  • Biology
    Annual review of pathology
  • 2011
TLDR
The gene defects in CRC often target proteins and pathways that exert pleiotropic effects on the cancer cell phenotype, and particular genetic and epigenetic alterations are linked to biologically and clinically distinct subsets of CRC.
...
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