Oral Contraceptive Pills as Primary Prevention for Ovarian Cancer: A Systematic Review and Meta-analysis

@article{Havrilesky2013OralCP,
  title={Oral Contraceptive Pills as Primary Prevention for Ovarian Cancer: A Systematic Review and Meta-analysis},
  author={L. Havrilesky and P. Moorman and W. Lowery and J. Gierisch and R. Coeytaux and R. Urrutia and M. Dinan and Amanda J. McBroom and V. Hasselblad and G. Sanders and E. Myers},
  journal={Obstetrics \& Gynecology},
  year={2013},
  volume={122},
  pages={139–147}
}
OBJECTIVE: To estimate the overall reduction in ovarian cancer risk associated with the use of oral contraceptive pills (OCPs) and whether reduction in risk is affected by specifics of OCP use, such as formulation or duration of use. DATA SOURCES: We searched PubMed, Embase, the Cochrane Database of Systematic Reviews, and ClinicalTrials.gov for studies published from January 1990 to June 2012, with primary analysis of studies published since January 2000. METHODS OF STUDY SELECTION: We… Expand
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Oral contraceptive pills as primary prevention for ovarian cancer: a systematic review and meta-analysis.
TLDR
The authors agree with the authors that oral contraceptive pill use can decrease the risk of developing ovarian cancer, but they believe that further studies still are required. Expand
Intrauterine Device Use and Ovarian Cancer Risk: A Systematic Review and Meta-analysis.
TLDR
Intrauterine device use is associated with a reduced incidence of ovarian cancer based on a review of existing retrospective data, and prospective investigation into the role of IUDs in ovarian cancer prevention is limited. Expand
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What are the mechanisms of action of the different contraceptive methods to reduce the risk of ovarian cancer?
TLDR
Combined hormonal contraceptive use is an effective method of chemoprevention for OvCa in the general population and in women with genetic disorders and salpingectomy, better than tubal ligation, should be offered for ovarian/tubal/peritoneal cancer prevention. Expand
The Chemoprevention of Ovarian Cancer: the Need and the Options
TLDR
The role of risk assessment in the design of chemoprevention strategies for OvCa is discussed, candidate agents are described, and future directions in this field are assessed. Expand
Cancer incidence attributable to the use of oral contraceptives and hormone therapy in Alberta in 2012.
TLDR
Based on estimates, oral contraceptive use resulted in a net protective effect among the cancer sites studied, thus reducing the cancer burden in Alberta in 2012. Expand
Interventions to reduce the risk of ovarian and fallopian tube cancer: A European Menopause and Andropause Society Postition Statement.
TLDR
In women with a genetic predisposition to ovarian cancer, salpingo-oophorectomy reduces the risk of ovarian malignancy, and to a lesser degree of breast cancer, and in premenopausal women, bilateral salpingectomy should be preferred to tubal ligation. Expand
Endocrine interventions in women with BRCA1/2 mutations
TLDR
Oral contraceptives seem to slightly increase the breast cancer risk of BRCA1/2 mutation carriers, but they also have a tremendous protective effect against ovarian cancer. Expand
Breastfeeding factors and risk of epithelial ovarian cancer.
TLDR
Although this association decreases over time, it persists for more than 30 years, and longer cumulative duration, increasing number of breastfeeding episodes, and earlier age at first breastfeeding episode are each associated with increased benefit. Expand
Trends in oral contraceptive and intrauterine device use among reproductive-aged women in the US from 1999 to 2017.
TLDR
Increasing IUD use outpaced declining OC use in premenopausal US women and there may be a resulting decreased gynecologic cancer risk as more women gain access to potentially risk-reducing contraceptives. Expand
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References

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TLDR
There is insufficient evidence to recommend for or against the use of OCs solely for the primary prevention of ovarian cancer, and the harm/benefit ratio was much more favorable when protection against endometrial and colorectal cancers was added. Expand
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TLDR
The present analysis indicates that, after taking into account duration of OC use, the OC protection from ovarian cancer persists for a long time after stopping use. Expand
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TLDR
The relationship between use of oral contraceptives and other contraceptive methods and the risk of ovarian cancer was examined in a combined analysis of 3 hospital‐based case‐control studies in Italy, the United Kingdom, and Greece, suggesting that the protection persists for 15 years or more after cessation of use and may be larger for use at younger age. Expand
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TLDR
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TLDR
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