Oral Carrageenan Induces Antigen-Dependent Oral Tolerance: Prevention of Anaphylaxis and Induction of Lymphocyte Anergy in a Murine Model of Food Allergy

@article{Frossard2001OralCI,
  title={Oral Carrageenan Induces Antigen-Dependent Oral Tolerance: Prevention of Anaphylaxis and Induction of Lymphocyte Anergy in a Murine Model of Food Allergy},
  author={Christophe P. Frossard and Conrad Hauser and Philippe A Eigenmann},
  journal={Pediatric Research},
  year={2001},
  volume={49},
  pages={417-422}
}
Immunosuppressive effects of carrageenan, a high-molecular-weight polysaccharide, on antibody and T cell responses have been previously demonstrated. However, its effect on anaphylaxis is unknown. Our objectives were to test carrageenan-mediated oral tolerance induction in young mice subsequently sensitized to a common cow's milk antigen. C3H/HeJ mice were fed or not λ-carrageenan (0.5 g/L) and/or 0.01 mg/mL β-lactoglobulin (BLG) for 5 d before oral sensitization with BLG and cholera toxin… CONTINUE READING

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