Oral Cancer and Mouthwash Use: Evaluation of the Epidemiologic Evidence

@article{Elmore1995OralCA,
  title={Oral Cancer and Mouthwash Use: Evaluation of the Epidemiologic Evidence},
  author={Joann G. Elmore and Ralph I Horwitz},
  journal={Otolaryngology- Head and Neck Surgery},
  year={1995},
  volume={113},
  pages={253 - 261}
}

Tables from this paper

Mouthwash and oral cancer risk quantitative meta-analysis of epidemiologic studies.
Alcohol-containing mouthwash and oral cancer risk: a review of current evidence
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While there is a lack of consistent evidence, it is advisable for clinicians to promote the use of non-alcoholic mouthwashes in order to minimise any potential increase in risk, and discourage long-term use of high alcohol-containing products.
Alcohol-containing mouthwash and oral cancer--can epidemiology prove the absence of risk?
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TLDR
It will probably never be possible to epidemiologically detect the low risk of alcohol-containing mouthwash, even with the most advanced statistical methodology in light of confounders such as drinking and smoking that may contribute to the same mechanism of carcinogenicity (acetaldehyde exposure).
Mouthwash in the etiology of oral cancer in Puerto Rico
TLDR
There was no overall increased risk of oral cancer associated with mouthwash use and an elevated, but not statistically significant, risk was observed among the small number of subjects who neither smoked cigarettes nor drank alcohol, among whom an effect of alcohol-containing mouthwash would be most likely evident.
Periodontal disease and mouthwash use are risk factors for head and neck squamous cell carcinoma
TLDR
The data suggest that mouthwash use is associated with HNSCC, but there is no difference between the effects of alcohol-containing and non-alcoholic mouthwashes.
Alcohol-containing Mouthwash and Oral Cancer Risk: A Systematic Review
TLDR
It proved that prolonged use of alcohol-based mouthwashes might cause oral cancers, and it’s advisable for the clinicians to educate patients about the ill-effects of long-term use of Alcohol-based Mouthwashes and to minimize the number of times it's used per day.
Mouthrinses containing alcohol and oral cancer: revision of epidemiological studies
TLDR
The purpose of the present paper is to analyze several epidemiological studies which evaluated the association between commercial mouthrinses and the etiology of OC.
The long-term effect of a mouthrinse containing essential oils on dental plaque and gingivitis: a systematic review.
TLDR
When used as an adjunct to unsupervised oral hygiene, EO provides an additional benefit with regard to plaque and gingivitis reduction as compared to a placebo or control.
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References

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Oral cancer and mouthwash.
TLDR
The findings and other reports of an increased risk among persons ordinarily at low risk of this disease raise the possibility that mouthwash may contribute to oral and pharyngeal cancers.
A study of the relationship between mouthwash use and oral and pharyngeal cancer.
TLDR
There is no evidence that mouthwash is a risk factor in the development of oral and pharyngeal cancer in males and logistic regression analysis revealed no significant differences in the frequency of mouthwash users in cancer cases versus controls.
Oral cancer and mouthwash use.
TLDR
It was not possible to attribute causal significance to the association between daily mouthwash use and oral cancer in women, because of the absence of a dose-response relationship and the possibility of confounding by tobacco and alcohol use.
Mouthwash use and oral conditions in the risk of oral and pharyngeal cancer.
TLDR
Risks of oral cancer were elevated among male and female mouthwash users, after adjusting for tobacco and alcohol consumption, and among both sexes generally increased in proportion to duration and frequency of mouthwash use.
Risk factors for oral cancer in women.
TLDR
Smoking, drinking, having 10 or more missing teeth, and religious background (non-Jewish versus Jewish) were significantly associated with oral cancer and mouthwash use was not associated with increased oral cancer risk.
Smoking and drinking in relation to oral and pharyngeal cancer.
TLDR
Risks of oropharyngeal cancer tended to combine more in a multiplicative than additive fashion and were increased more than 35-fold among those who consumed two or more packs of cigarettes and more than four alcoholic drinks/day.
Comparative epidemiology of tobacco-related cancers.
TLDR
Greater smoking habits and lesser cessation rates were noted among lower socioeconomic groups, suggesting that these groups will bear an ever increasing proportion of the burden of tobacco-related cancer.
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