Oral Bioavailability Enhancement of Exemestane from Self-Microemulsifying Drug Delivery System (SMEDDS)

@article{Singh2009OralBE,
  title={Oral Bioavailability Enhancement of Exemestane from Self-Microemulsifying Drug Delivery System (SMEDDS)},
  author={Ajeet Kumar Singh and Akash Chaurasiya and Anshumali Awasthi and Gautam Mishra and Dinesh Prasad Asati and Roop Krishen Khar and Rama Mukherjee},
  journal={AAPS PharmSciTech},
  year={2009},
  volume={10},
  pages={906-916}
}
Limited aqueous solubility of exemestane leads to high variability in absorption after oral administration. To improve the solubility and bioavailability of exemestane, the self-microemulsifying drug delivery system (SMEDDS) was developed. SMEDDS comprises of isotropic mixture of natural or synthetic oil, surfactant, and cosurfactant, which, upon dilution… CONTINUE READING