Oral Anticoagulants: Pharmacodynamics, Clinical Indications and Adverse Effects

@article{Freedman1992OralAP,
  title={Oral Anticoagulants: Pharmacodynamics, Clinical Indications and Adverse Effects},
  author={Michael D. Freedman},
  journal={The Journal of Clinical Pharmacology},
  year={1992},
  volume={32}
}
  • M. D. Freedman
  • Published 1 March 1992
  • Medicine
  • The Journal of Clinical Pharmacology
Discovered early in this century consequent to investigations of a bovine hemorrhagic disease, the oral anticoagulants inhibit a post translational modification required for various hepatically derived serine proteases to become active. These include Factors II, V, VII and X. Through their effect on Proteins S and C, the extrinsic pathway is also effected. While most of these agents exist as optically active enantiomers, with differing kinetics and pharmacologic profiles, they are generally… 
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