Oral Antibiotic Treatment of Mice Exacerbates the Disease Severity of Multiple Flavivirus Infections

@inproceedings{Thackray2018OralAT,
  title={Oral Antibiotic Treatment of Mice Exacerbates the Disease Severity of Multiple Flavivirus Infections},
  author={Larissa B. Thackray and Scott A Handley and Matthew J. Gorman and Subhajit Poddar and Prachi Bagadia and Carlos G. Brise{\~n}o and Derek J Theisen and Qing Tan and Barry L. Hykes and Hueylie Lin and Tiffany M. Lucas and Chandni Desai and Jeffrey I. Gordon and Kenneth M Murphy and Herbert W Virgin and Michael S Diamond},
  booktitle={Cell reports},
  year={2018}
}
Although the outcome of flavivirus infection can vary from asymptomatic to lethal, environmental factors modulating disease severity are poorly defined. Here, we observed increased susceptibility of mice to severe West Nile (WNV), Dengue, and Zika virus infections after treatment with oral antibiotics (Abx) that depleted the gut microbiota. Abx treatment impaired the development of optimal T cell responses, with decreased levels of WNV-specific CD8+ T cells associated with increased infection… CONTINUE READING

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