Oral Administration of Pregabalin in Rats before or after Nerve Injury Partially Prevents Spontaneous Neuropathic Pain and Long Outlasts the Treatment Period.

@article{Wang2016OralAO,
  title={Oral Administration of Pregabalin in Rats before or after Nerve Injury Partially Prevents Spontaneous Neuropathic Pain and Long Outlasts the Treatment Period.},
  author={Ran-ran Wang and Guo-dong Lou and Jie Yu and Ting-Ting Hu and Wei-wei Hou and Zhong Chen and Shi-Hong Zhang and Ze''ev Seltzer},
  journal={Pharmacology},
  year={2016},
  volume={97 5-6},
  pages={251-8}
}
BACKGROUND AND METHODS Pregabalin alleviates stimulus-evoked neuropathic pain (NeuP) in some pain patients and rodents in models of painful neuropathies. But it is not known if pregabalin can also alleviate spontaneous NeuP. Sciatic and saphenous neurectomy in rats elicits spontaneous self-mutilation of the denervated hindpaw, a behavior that models… CONTINUE READING