Oral Administration of Lactobacillus plantarum Strain AYA Enhances IgA Secretion and Provides Survival Protection against Influenza Virus Infection in Mice

@article{Kikuchi2014OralAO,
  title={Oral Administration of Lactobacillus plantarum Strain AYA Enhances IgA Secretion and Provides Survival Protection against Influenza Virus Infection in Mice},
  author={Yosuke Kikuchi and Ayami Kunitoh-Asari and Katsuyuki Hayakawa and Shinjiro Imai and Kenji Kasuya and Kimio Abe and Yu Adachi and Shin-ichi Fukudome and Yoshimasa Takahashi and Satoshi Hachimura},
  journal={PLoS ONE},
  year={2014},
  volume={9}
}
The mucosal immune system provides the first line of defense against inhaled and ingested pathogenic microbacteria and viruses. This defense system, to a large extent, is mediated by the actions of secretory IgA. In this study, we screened 140 strains of lactic acid bacteria for induction of IgA production by murine Peyer’s patch cells. We selected one strain and named it Lactobacillus plantarum AYA. We found that L. plantarum AYA-induced production of IL-6 in Peyer’s patch dendritic cells… Expand
In vivo dose response and in vitro mechanistic analysis of enhanced immunoglobulin A production by Lactobacillus plantarum AYA
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