Oral Absorption of Peptides Through the Cobalamin (Vitamin B12) Pathway in the Rat Intestine

@article{Alsenz2000OralAO,
  title={Oral Absorption of Peptides Through the Cobalamin (Vitamin B12) Pathway in the Rat Intestine},
  author={Jochem Alsenz and Greg J. Russell-Jones and Steven Westwood and Bernard Levet-Trafit and P. Chris de Smidt},
  journal={Pharmaceutical Research},
  year={2000},
  volume={17},
  pages={825-832}
}
Purpose. This study was aimed at examining the extent and mechanismof uptake of cobalamin (Cbl)-conjugated peptides in vitro and in vivo. Methods. To enable acquisition of quantitative absorption data ofCbl-peptides, metabolically stable octapeptides (DP3), with (Cbl-Hex-DP3)or without a hexyl spacer (Cbl-DP3), were coupled to Cbl andradiolabeled. For comparison, LHRH coupled to Cbl was used as metabolicallysusceptible peptide. Biological recognition of Cbl-peptides was studiedin the… CONTINUE READING