Oral Absorption of FK506 in Rats

  title={Oral Absorption of FK506 in Rats},
  author={Akira Kagayama and Sachiyo Tanimoto and Jiro Fujisaki and Atunori Kaibara and Kaname Ohara and Kazuhide Iwasaki and Yuri Hirano and Takehisa Hata},
  journal={Pharmaceutical Research},
The oral absorption of FK506 in solid dispersion formulation was studied in rats. The obtained area under the concentration versus time curve (AUC) increased in a nonlinear fashion with a small dose-dependent increase in the peak blood concentrations (C max). The peak concentration time (T max) was observed within 30 min after administration in all dosing groups (1–10 mg/kg) with or without feeding, whereas the oral absorption of FK506 was reduced to about 50% by gavage at a dose of 1 mg/kg… CONTINUE READING


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