Oral 18F-fluoro-2-deoxyglucose for primate PET studies without behavioral restraint: demonstration of principle.

Abstract

We describe a method of orally administering 18F-fluoro-2-deoxyglucose (FDG) for positron emission tomography (PET) scans to determine local cerebral metabolic rates for glucose (LCMRGlc), normalized to that of whole brain, in fully conscious, non-restrained primates. Oral FDG-PET studies were performed in both non-restrained and chaired monkeys, and in one human where results could be compared with traditional intravenous FDG administration. The oral route of FDG administration gave images and whole brain-normalized PET LCMRGlc results comparable to those obtained by the intravenous route. This oral FDG-PET method may provide a useful means by which to obtain measures of LCMRGlcs for brain structures, relative to each other, in non-restrained, non-drugged primates in field and laboratory studies. This method might also have clinical applications for PET studies of children.

Statistics

010020030020102011201220132014201520162017
Citations per Year

335 Citations

Semantic Scholar estimates that this publication has 335 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Martinez1997Oral1F, title={Oral 18F-fluoro-2-deoxyglucose for primate PET studies without behavioral restraint: demonstration of principle.}, author={Zoe A. Martinez and Michael B Colgan and Lewis R. Baxter and Josefina Quintana and Stefan B Siegel and Arion Chatziioannou and Simon R. Cherry and John C. Mazziotta and M. E. Phelps}, journal={American journal of primatology}, year={1997}, volume={42 3}, pages={215-24} }