Oral 1α, 25-dihydroxycholecalciferol (1,25 Dhcc) in the Treatment of Childhood Renal Osteodystrophy

Central to the development of renal osteodystrophy is the failure of the kidney to produce sufficient amounts of the most active natural vitamin D metabolite 1,25 DHCC. We have initiated oral therapy with 1,25 DHCC at 10-30 ngm/kg daily in 6 uremic children attempting to reverse bone disease or prevent further change. Patients with hypocalcemia or X-ray… CONTINUE READING