Oral, short-term exposure to titanium dioxide nanoparticles in Sprague-Dawley rat: focus on reproductive and endocrine systems and spleen.

@article{Tassinari2014OralSE,
  title={Oral, short-term exposure to titanium dioxide nanoparticles in Sprague-Dawley rat: focus on reproductive and endocrine systems and spleen.},
  author={Roberta Tassinari and Francesco Cubadda and Gabriele Moracci and Federica Aureli and Marilena D'Amato and M. Valeri and Barbara De Berardis and Andrea Raggi and Alberto Mantovani and Daniele Passeri and Marco Rossi and Francesca Maranghi},
  journal={Nanotoxicology},
  year={2014},
  volume={8 6},
  pages={654-62}
}
The study explored possible reproductive and endocrine effects of short-term (5 days) oral exposure to anatase TiO2 nanoparticles (0, 1, 2 mg/kg body weight per day) in rat. Nanoparticles were characterised by scanning electron microscopy (SEM) and transmission electron microscopy, and their presence in spleen, a target organ for bioaccumulation, was investigated by single-particle inductively coupled plasma mass spectrometry and SEM/energy-dispersive X-ray. Analyses included serum hormone… CONTINUE READING
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