Oral, direct thrombin and factor Xa inhibitors: the replacement for warfarin, leeches, and pig intestines?

@article{Straub2011OralDT,
  title={Oral, direct thrombin and factor Xa inhibitors: the replacement for warfarin, leeches, and pig intestines?},
  author={Alexander Straub and Susanne R{\"o}hrig and Alexander Hillisch},
  journal={Angewandte Chemie},
  year={2011},
  volume={50 20},
  pages={4574-90}
}
To prevent thromboses after surgery, patients have until now had to inject themselves daily with heparin. For stroke prophylaxis in atrial fibrillation, patients take vitamin K antagonists of the coumarin type, which have a narrow therapeutic window and whose dosage must be regularly monitored. In order to improve the standard of therapy in thromboembolic… CONTINUE READING