Oral, Intraperitoneal and Intravenous Pharmacokinetics of Deramciclane and its N‐desmethyl Metabolite in the Rat

@article{Nemes2000OralIA,
  title={Oral, Intraperitoneal and Intravenous Pharmacokinetics of Deramciclane and its N‐desmethyl Metabolite in the Rat},
  author={K. Nemes and M. Abermann and E. Bojti and G. Gr{\'e}zal and S. al-Behaisi and I. Klebovich},
  journal={Journal of Pharmacy and Pharmacology},
  year={2000},
  volume={52}
}
The pharmacokinetic properties of deramciclane fumarate (EGIS‐3886), a new potential anxiolitic agent, and its N‐desmethyl metabolite have been investigated in Wistar rats after 10 mg kg−1 deramciclane fumarate was administered orally, intraperitoneally or intravenously. 
Studies of the side chain cleavage of deramciclane in rats with radiolabelled compounds.
Influence of food on the oral bioavailability of deramciclane from film-coated tablet in healthy male volunteers.
  • S. Drabant, K. Nemes, +8 authors I. Klebovich
  • Chemistry, Medicine
  • European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
  • 2004
BIOTRANSFORMATION OF DERAMCICLANE IN PRIMARY HEPATOCYTES OF RAT, MOUSE, RABBIT, DOG, AND HUMAN
In vitro simulation of food effect on dissolution of deramciclane film-coated tablets and correlation with in vivo data in healthy volunteers.
  • S. al-Behaisi, I. Antal, +4 authors I. Klebovich
  • Chemistry, Medicine
  • European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
  • 2002
Intraperitoneal chemotherapy of ovarian cancer by hydrogel depot of paclitaxel nanocrystals.
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References

SHOWING 1-10 OF 14 REFERENCES
Plasma Protein Binding of Deramciclane in Different Species
Absorption of the new anxiolytic compound deramciclane in rats, dogs and rabbits.
Absorption and pharmacokinetics of deramciclane in rat
  • Arch . Pharm
  • 1998
Fate of radiolabelled deramciclane (EGIS-3886) in rats, pharmacokinetics, excretion and separation of potential metabolites
  • ISSX Proceedings
  • 1997
A high sensitive GC method for the determination of deramciclane and its N - desmethyl metabolite in rat and dog plasma
  • 1996
Different antagonistic activity of deramciclane ( EGIS - 3886 ) on peripheral and central 5 - HT 2 receptors
  • Pharm . Pharmacol . Lett .
  • 1996
...
1
2
...