Orai1 regulates intracellular calcium, arrest, and shape polarization during neutrophil recruitment in shear flow.

@article{Schaff2010Orai1RI,
  title={Orai1 regulates intracellular calcium, arrest, and shape polarization during neutrophil recruitment in shear flow.},
  author={Ulrich Y. Schaff and Neha Dixit and Emily Procyk and Itsukyo Yamayoshi and Tiffany Tse and Scott I Simon},
  journal={Blood},
  year={2010},
  volume={115 3},
  pages={657-66}
}
Orai1 was reported to function as a calcium channel subunit that facilitates store operated calcium entry (SOCE) in T cells and is necessary for formation of the immune synapse. We reasoned that SOCE via Orai1 might regulate PMNs activation during recruitment to inflamed endothelium. Orai1 function was assessed by real-time imaging of calcium transients as PMNs were stimulated to roll, arrest, and migrate on E-selectin and ICAM-1 in shear flow. Calcium entry was significantly reduced when Orai1… CONTINUE READING
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