Orai1 and STIM1 are critical for cell migration and proliferation of clear cell renal cell carcinoma.

@article{Kim2014Orai1AS,
  title={Orai1 and STIM1 are critical for cell migration and proliferation of clear cell renal cell carcinoma.},
  author={Ji-Hee Kim and Sayamaa Lkhagvadorj and Mi-Ra Lee and Kyu-Hee Hwang and Hyun Chul Chung and Jae Hung Jung and Seung-Kuy Cha and Minseob Eom},
  journal={Biochemical and biophysical research communications},
  year={2014},
  volume={448 1},
  pages={76-82}
}
The intracellular Ca(2+) regulation has been implicated in tumorigenesis and tumor progression. Notably, store-operated Ca(2+) entry (SOCE) is a major Ca(2+) entry mechanism in non-excitable cells, being involved in cell proliferation and migration in several types of cancer. However, the expression and biological role of SOCE have not been investigated in clear cell renal cell carcinoma (ccRCC). Here, we demonstrate that Orai1 and STIM1, not Orai3, are crucial components of SOCE in the… CONTINUE READING
Highly Cited
This paper has 67 citations. REVIEW CITATIONS

4 Figures & Tables

Topics

Statistics

0204020142015201620172018
Citations per Year

68 Citations

Semantic Scholar estimates that this publication has 68 citations based on the available data.

See our FAQ for additional information.